It is a well known fact that muscles in your hand and arm get used to all sorts of actions and positions.
This of course applies specifically to the standard mouse which is generally too small for your hand. It forces your hand and fingers in an awkward position to be able to hold onto the mouse. For example thumb and little finger have to  grip the mouse while the other 3 fingers sort of hang over the mouse, this to prevent inadvertent switching. Not only is this position of the hand uncomfortable, it results in excessive muscle tension with detrimental effects. One of the first signs is pain in and around the wrist and around the upper part of the forearm, the elbow. When you continue working like this, these stresses can even result in pain in shoulders and neck. (Ref. www.handshoemouse.com/research.html)

Therefore the Erasmus University Medical Center, looked at the possibility to relieve the computer mouse user of these unnecessary stresses and strains. During the initial fundamental research professor Chris Snijders and drs. ing. Paul Helder showed that a good hand support could reduce or even eliminate these unnecessary muscle forces. The subsequent field study substantiated this.
We are proud to mention that during EMG measurements with the Medical Faculty of the University of Maastricht it was shown that our assumptions were correct.
Now, after a number of years, having gained experience with the HandShoe Mouse, we are of the opinion that this truly ergonomic mouse provides the necessary relief to reduce the risk of RSI complaints to a minimum.
 
Always Use Your Ergonomic Mouse At home Too

 For example, a number of HandShoe Mouse users state, that when using another, conventional mouse at home, while using the HandShoe Mouse in the office, the aforementioned stresses and strains in hands and fingers immediately re-occur
That’s why we advise to take the HandShoe Mouse with you and use it everywhere you work with PC or laptop. The HandShoe Mouse cable, which is an industry standard cable, can easily be disconnected from the mouse. And if you have a spare cable at home, you can simply connect the HandShoe Mouse to your home PC. If you use a wireless HandShoe Mouse version, make sure you also bring the dongle (micro receiver) which takes care of the communication between mouse and computer. 
Thus it is very easy to connect the mouse when you have cables connected to the various work stations you use.